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Cell Therapy & Gene Therapy

The development of any cell and gene therapy must overcome multiple challenges to avoid failed treatments.

There is a lack of clinically validated tools available to researchers to aid in the monitoring cellular status in a reliable way, and hence contributing to the decision-making process during therapy development.

Cell characterization, vector monitoring and quality assurance through a comprehensive panel of multiple biomarkers can help you address these problems while saving time and money.

CELL THERAPIES

Cell monitoring and characterization:

  • Cells with short telomeres are closer to senescence. Ensure an optimal telomere length to improve in vivo survival.
  • Verify telomeres are long enough in order to protect plasticity in stem cell-like cells.
  • Stain and measure specific cells types. Ideal for xenografts, focus on different cell populations, origins, etc.
  • Determine cell infiltration and specific cell-type markers (mTOR, PD1-PDL1, ILs…)

Donor/ sample selection:

  • Ensure that you start your cell expansions/processing with the best samples.

Biosafety:

  • Hyperactivated telomerase activity is a hallmark of cancer. Monitor telomerase activity to discard potential tumorigenicity after cellular expansions or modifications.
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GENE THERAPIES

Cells are widely used in gene therapy for multiple purposes. Evaluate cellular status after introducing modifications through telomere length and other important markers.

Monitor everything around the expression of your gene therapy:

  • Confirm and quantify the expression of the gene editing system on your target population.
  • Compare and select the vector with the most optimal response.
  • Asses viral tropism and the successful delivery of the desired gene.
  • Distinguish transgene from vector genome ensuring the transfer of the desired gene.
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APPLIED EXAMPLES

Select the best donor:

Cells with longer telomeres will take more time to achieve senescence.

Monitor your expansion and how far are cells from senescence:

Measure telomere length thorough the whole expansion.

Telomerase activity monitoring:

Quality control. Elevated telomerase levels are associated with tumorigenesis.

Telomere length measurement

Guarantee in vivo survival.

Xenografts

Murine cells (green) and human cancer cells (pink).

CART-T

Detect CAR-T cells in tumor.

VACCINE IMMUNE RESPONSE

VACCINE IMMUNE RESPONSE

Identify specific cytokines after antigen stimulation

TELOMERASE ACTIVITY MONITORING

Telomerase activity inhibition by oncology therapy

TELOMERE ANALYSIS

Robust data for your scientific publications , IP patents, Posters for congresses and other promotional/marketing materials.

DONOR SELECTION IN CELL THERAPIES

Robust data for your scientific publications , IP patents, Posters for congresses and other promotional/marketing materials.
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DO YOU WANT MORE INFORMATION?

For further information or enquiries please contact contractresearch@lifelength.com or leave your details on this form.

DO YOU WANT MORE INFORMATION?

For further information or enquiries please contact info@lifelength.com or leave your details on this form.

We inform our valued customer community that we have made the difficult decision to close our General Martinez Campos clinic.

However, we want to assure our customers that Life Length will continue to provide its proprietary telomere measurement services and HealthTAV®, HealthOX and HealthNAD+ assays in more than 35 countries. We will also continue to work closely with physicians and clinics committed to personalised medicine, longevity and healthy ageing.

It is a true privilege and honour to have had the opportunity to serve and assist tens of thousands of clients who have placed their trust in our clinic since the beginning of the pandemic. We express our deepest appreciation.

If you have any questions or queries, please do not hesitate to write to us at info@lifelength.com. We are here to help you in any way we can.

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For further information or enquiries, please leave your details on this form.

DO YOU WANT MORE INFORMATION?

For further information or enquiries please contact oncologydiagnostics@lifelength.com or leave your details on this form.

DO YOU WANT MORE INFORMATION?

For further information or enquiries please contact clinica@lifelength.com or leave your details on this form.

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