Aula

Telomeres 101

Tómese su tiempo para explorar la gran selección de vídeos, presentaciones y artículos científicos sobre telómeros. Haga click en Soy nuevo en esto! si es la primera vez que va a leer algo sobre telómeros. Nuestra sección de Telómeros y Enfermedades le dará una visión profunda de recientes publicaciones que relacionan los telómeros con enfermedades ligadas a la edad. Si eres médico, te recomendamos visitar la sección Consejos clínicos para entender la aplicación clínica que tiene el análisis de los telómeros y cómo aplicarla en su práctica médica diaria. Si usted quiere realizar su propia investigación visite la sección Artículos científicos que le proporcionará una lista de las publicaciones más actuales sobre telómeros.

SOY NUEVO EN ESTO!

Presentación clínica para el análisis telomérico

 

Presentación clínica avanzada para el análisis telomérico

 

HÁBITOS DE VIDA PARA UNOS TELÓMEROS SANOS

 

What are telomeres and why should I have them measured?

 

What is your true age?

 

Facts on Aging and health

 

Lifestyle practices to maintain telomere length

 

Telomere Biology

 

Telomere Biology – part 2

 

TELÓMEROS Y ENFERMEDADES

TAT in risk detection and prevention of cardiovascular disease

 

Metabolic diseases diet, nutrition, & obesity

 

TAT as a biomarker to assess the risk of cancer

 

Telomeros, envejecimiento y prevencion Dr.A.Fernandez-Cruz – Barcelona – April 2014

 

The connection between Telomeres and Aging-Dr. Patana teng-umnuay

 

El origen de la enfermedad- Dra. Maria Blasco Madrid – April 2014

 

 

Aging and the telomere connection dr. Jerry W. Shay – April 2012

 

CONSEJOS CLÍNICOS

Clinical use of telomere measurement in preventive and personalized medicine dr. Dave Woynarowski – May 2014

 

The clinical value of telomere testing

 

 

 

HOW TO EXPLAIN LIFE LENGTH’S TAT RESULTS TO PATIENTS

 

 

 

AMMG Las Vegas 2012 Dr Bill Andrews

 

 

Dr. Bill Andrews at 13th annual AMMG, Las Vegas, Nov 2012

 

The Clinical Value of Telomere Testing – Dr. Mark Tager – A4M May 2016

 

ARTÍCULOS CIENTÍFICOS

ENVEJECIMIENTO

1.-  Number of Children and Telomere Length in Women: A Prospective, Longitudinal Evaluation
Barha CK, Hanna CW, Salvante KG, Wilson SL, Robinson WP, Altman RM, Nepomnaschy PA.
PLoS One. 2016 Jan 5;11(1):e0146424. doi: 10.1371/journal.pone.0146424. eCollection 2016.
PMID: 26731744

 

2.- Biomolecular Markers Within the Core Axis of Aging and Particulate Air Pollution Exposure in the Elderly: A Cross-Sectional Study
Pieters N, Janssen BG, Dewitte H, Cox B, Cuypers A, Lefebvre W, Smeets K, Vanpoucke C, Plusquin M, Nawrot TS.
Environ Health Perspect. 2015 Dec 15. [Epub ahead of print]
PMID: 26672058

3.- Circulating leukocyte telomere length is highly heritable among families of Arab descent
Al-Attas OS, Al-Daghri NM, Alokail MS, Alkharfy KM, Alfadda AA, McTernan P, Gibson GC, Sabico SB, Chrousos GP.
BMC Med Genet. 2012 May 18;13:38.
PMID: 22606980

 

4.- Quantification of biological aging in young adults.
Belsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE.
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4104-10. doi: 10.1073/pnas.1506264112. Epub 2015 Jul 6.
PMID: 26150497

 

5.- How old do you feel? The role of age discrimination and biological aging in subjective age.
Stephan Y, Sutin AR, Terracciano A.
PLoS One. 2015 Mar 4;10(3):e0119293. doi: 10.1371/journal.pone.0119293. eCollection 2015.
PMID: 25738579

 

6.- MARK-AGE biomarkers of ageing.
Bürkle A, Moreno-Villanueva M, Bernhard J, Blasco M, Zondag G, Hoeijmakers JH, Toussaint O, Grubeck-Loebenstein B, Mocchegiani E, Collino S, Gonos ES, Sikora E, Gradinaru D, Dollé M, Salmon M, Kristensen P, Griffiths HR, Libert C, Grune T, Breusing N, Simm A, Franceschi C, Capri M, Talbot D, Caiafa P, Friguet B, Slagboom PE, Hervonen A, Hurme M, Aspinall R.
Mech Ageing Dev. 2015 Nov;151:2-12. doi: 10.1016/j.mad.2015.03.006. Epub 2015 Mar 24.
PMID: 25818235

 

7.- Cellular aging and restorative processes: subjective sleep quality and duration moderate the association between age and telomere length in a sample of middle-aged and older adults.
Cribbet MR, Carlisle M, Cawthon RM, Uchino BN, Williams PG, Smith TW, Gunn HE, Light KC.
Sleep. 2014 Jan 1;37(1):65-70. doi: 10.5665/sleep.3308.
PMID: 24470696

 

7.- Association between telomere length in blood and mortality in people aged 60 years or older.
Cawthon RM, Smith KR, O’Brien E, Sivatchenko A, Kerber RA.
Lancet. 2003 Feb 1;361(9355):393-5.
PMID: 12573379

CANCER
Cáncer de pecho

 

1.-  Biological ageing and frailty markers in breast cancer patients.
Brouwers B, Dalmasso B, Hatse S, Laenen A, Kenis C, Swerts E, Neven P, Smeets A, Schöffski P, Wildiers H.
Aging (Albany NY). 2015 May;7(5):319-33.
PMID: 25989735
2.-  Impact of chemotherapy on telomere length in sporadic and familial breast cancer patients.
Benitez-Buelga C, Sanchez-Barroso L, Gallardo M, Apellániz-Ruiz M, Inglada-Pérez L, Yanowski K, Carrillo J, Garcia-Estevez L, Calvo I, Perona R, Urioste M, Osorio A, Blasco MA, Rodriguez-Antona C, Benitez J.
Breast Cancer Res Treat. 2015 Jan;149(2):385-94. doi: 10.1007/s10549-014-3246-6. Epub 2014 Dec 21.
PMID: 25528024
3.- Short telomeres are frequent in hereditary breast tumors and are associated with high tumor grade.
Martinez-Delgado B, Gallardo M, Tanic M, Yanowsky K, Inglada-Perez L, Barroso A, Rodriguez-Pinilla M, Cañamero M, Blasco MA, Benitez J.
Breast Cancer Res Treat. 2013 Sep;141(2):231-42. doi: 10.1007/s10549-013-2696-6. Epub 2013 Sep 15.
PMID: 24036693

Cáncer de colon

 

1.- The prognostic factors and multiple biomarkers in young patients with colorectal cancer.
BWang MJ, Ping J, Li Y, Adell G, Arbman G, Nodin B, Meng WJ, Zhang H, Yu YY, Wang C, Yang L, Zhou ZG, Sun XF.
Sci Rep. 2015 May 27;5:10645. doi: 10.1038/srep10645.
PMID: 26013439
2.- Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer.
Augustine TA, Baig M, Sood A, Budagov T, Atzmon G, Mariadason JM, Aparo S, Maitra R, Goel S.
Br J Cancer. 2015 Jan 20;112(2):313-8. doi: 10.1038/bjc.2014.561. Epub 2014 Nov 20.
PMID: 25412235
3.- Telomeres, telomerase and colorectal cancer.
Bertorelle R, Rampazzo E, Pucciarelli S, Nitti D, De Rossi A.
World J Gastroenterol. 2014 Feb 28;20(8):1940-50. doi: 10.3748/wjg.v20.i8.1940. Review.
PMID: 24616570
4.- Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability.
Roger L, Jones RE, Heppel NH, Williams GT, Sampson JR, Baird DM.
J Natl Cancer Inst. 2013 Aug 21;105(16):1202-11. doi: 10.1093/jnci/djt191. Epub 2013 Aug 5.
PMID: 23918447

Leucemia

 

1.- Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.
Strefford JC, Kadalayil L, Forster J, Rose-Zerilli MJ, Parker A, Lin TT, Heppel N, Norris K, Gardiner A, Davies Z, Gonzalez de Castro D, Else M, Steele AJ, Parker H, Stankovic T, Pepper C, Fegan C, Baird D, Collins A, Catovsky D, Oscier DG.
Leukemia. 2015 Dec;29(12):2411-4. doi: 10.1038/leu.2015.217. Epub 2015 Aug 10. No abstract available.
PMID: 26256637

Cáncer de pulmón

 

1.- Genetic Polymorphism, Telomere Biology and Non-Small Lung Cancer Risk.
Wei R, DeVilbiss FT, Liu W.
J Genet Genomics. 2015 Oct 20;42(10):549-61. doi: 10.1016/j.jgg.2015.08.005. Epub 2015 Sep 14. Review.
PMID: 26554909

Uso prognóstico de la medida de la longitud telomérica

 

1.- Strong association between long and heterogeneous telomere length in blood lymphocytes and bladder cancer risk in Egyptian.
Wang H, Wang Y, Kota KK, Kallakury B, Mikhail NN, Sayed D, Mokhtar A, Maximous D, Yassin EH, Gouda I, Sobitan A, Sun B, Loffredo CA, Zheng YL.
Carcinogenesis. 2015 Nov;36(11):1284-90. doi: 10.1093/carcin/bgv121. Epub 2015 Sep 5.
PMID: 26342126

2.- Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort.
Hou L, Joyce BT, Gao T, Liu L, Zheng Y, Penedo FJ, Liu S, Zhang W, Bergan R, Dai Q, Vokonas P, Hoxha M, Schwartz J, Baccarelli A.
EBioMedicine. 2015 Apr 13;2(6):591-6. doi: 10.1016/j.ebiom.2015.04.008. eCollection 2015 Jun.
PMID: 26288820

3.- Telomere length and telomerase activity in non-small cell lung cancer prognosis: clinical usefulness of a specific telomere status.
Fernández-Marcelo T, Gómez A, Pascua I, de Juan C, Head J, Hernando F, Jarabo JR, Calatayud J, Torres-García AJ, Iniesta P.
J Exp Clin Cancer Res. 2015 Aug 7;34:78. doi: 10.1186/s13046-015-0195-9.
PMID: 26250468

4.- Prognostic value of telomere function in gastric cancers with and without microsatellite instability.
Pascua I, Fernández-Marcelo T, Sánchez-Pernaute A, de Juan C, Head J, Torres-García AJ, Iniesta P.
Eur J Gastroenterol Hepatol. 2015 Feb;27(2):162-9. doi: 10.1097/MEG.0000000000000250.
PMID: 25486025
5.- Telomere length and risk of incident cancer and cancer mortality.
Willeit P, Willeit J, Mayr A, Weger S, Oberhollenzer F, Brandstätter A, Kronenberg F, Kiechl S.
JAMA. 2010 Jul 7;304(1):69-75. doi: 10.1001/jama.2010.897.
PMID: 20606151
5.- Are short telomeres predictive of advanced cancer?
Shay JW.
Cancer Discov. 2013 Oct;3(10):1096-8. doi: 10.1158/2159-8290.CD-13-0506.
PMID: 24124228

ENFERMEDADES CARDIOVASCULARES

1.-  Telomere length, cardiovascular risk and arteriosclerosis in human kidneys: an observational cohort study.
De Vusser K, Pieters N, Janssen B, Lerut E, Kuypers D, Jochmans I, Monbaliu D, Pirenne J, Nawrot T, Naesens M.
Aging (Albany NY). 2015 Oct;7(10):766-75.
PMID: 26539975

 

2.- Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis.
Haycock PC, Heydon EE, Kaptoge S, Butterworth AS, Thompson A, Willeit P.
BMJ. 2014 Jul 8;349:g4227. doi: 10.1136/bmj.g4227. Review.
PMID: 25006006

 

3.- Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial.
Haver VG, Hartman MH, Mateo Leach I, Lipsic E, Lexis CP, van Veldhuisen DJ, van Gilst WH, van der Horst IC, van der Harst P.
Clin Res Cardiol. 2015 Oct;104(10):812-21. doi: 10.1007/s00392-015-0848-x. Epub 2015 Apr 4.
PMID: 25840550

 

4.- Telomeres and cardiovascular disease risk: an update 2013.
Nilsson PM, Tufvesson H, Leosdottir M, Melander O.
Transl Res. 2013 Dec;162(6):371-80. doi: 10.1016/j.trsl.2013.05.004. Epub 2013 Jun 7. Review.
PMID: 23748031

DIABETES

1.- Associations of TERC Single Nucleotide Polymorphisms with Human Leukocyte Telomere Length and the Risk of Type 2 Diabetes Mellitus.
Al Khaldi R, Mojiminiyi O, AlMulla F, Abdella N.
PLoS One. 2015 Dec 31;10(12):e0145721. doi: 10.1371/journal.pone.0145721. eCollection 2015.
PMID: 26720590

 

2.- Telomere mean length in patients with diabetic retinopathy.
Sharma R, Gupta A, Thungapathra M, Bansal R.
Sci Rep. 2015 Dec 16;5:18368. doi: 10.1038/srep18368.
PMID: 26670612

 

3.- Differential Telomere Shortening in Blood versus Arteries in an Animal Model of Type 2 Diabetes.
Tajbakhsh S, Aliakbari K, Hussey DJ, Lower KM, Donato AJ, Sokoya EM.
J Diabetes Res. 2015;2015:153829. doi: 10.1155/2015/153829. Epub 2015 Aug 6.
PMID: 26346823

 

4.- Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases.
Strazhesko I, Tkacheva O, Boytsov S, Akasheva D, Dudinskaya E, Vygodin V, Skvortsov D, Nilsson P.
PLoS One. 2015 Aug 26;10(8):e0136676. doi: 10.1371/journal.pone.0136676. eCollection 2015.
PMID: 26308091

5.- Short telomere length is associated with arterial aging in patients with type 2 diabetes mellitus.
Dudinskaya EN, Tkacheva ON, Shestakova MV, Brailova NV, Strazhesko ID, Akasheva DU, Isaykina OY, Sharashkina NV, Kashtanova DA, Boytsov SA.
Endocr Connect. 2015 Sep;4(3):136-43. doi: 10.1530/EC-15-0041. Epub 2015 Jun 1.
PMID: 26034119

DIETA Y NUTRICIÓN

1.- 1.- Associations of TERC Single Nucleotide Polymorphisms with Human Leukocyte Telomere Length and the Risk of Type 2 Diabetes Mellitus.
Al Khaldi R, Mojiminiyi O, AlMulla F, Abdella N.
PLoS One. 2015 Dec 31;10(12):e0145721. doi: 10.1371/journal.pone.0145721. eCollection 2015.
PMID: 26720590

 

2.- Prenatal undernutrition and leukocyte telomere length in late adulthood: the Dutch famine birth cohort study.
de Rooij SR, van Pelt AM, Ozanne SE, Korver CM, van Daalen SK, Painter RC, Schwab M, Viegas MH, Roseboom TJ.
Am J Clin Nutr. 2015 Sep;102(3):655-60. doi: 10.3945/ajcn.115.112326. Epub 2015 Jul 15.
PMID: 26178721

 

3.- Mediterranean diet and leukocyte telomere length in a multi-ethnic elderly population.
Gu Y, Honig LS, Schupf N, Lee JH, Luchsinger JA, Stern Y, Scarmeas N.
Age (Dordr). 2015;37(2):24. doi: 10.1007/s11357-015-9758-0. Epub 2015 Mar 8.
PMID: 25750063

 

4.- Soda and cell aging: associations between sugar-sweetened beverage consumption and leukocyte telomere length in healthy adults from the National Health and Nutrition Examination Surveys.
Leung CW, Laraia BA, Needham BL, Rehkopf DH, Adler NE, Lin J, Blackburn EH, Epel ES.
Am J Public Health. 2014 Dec;104(12):2425-31. doi: 10.2105/AJPH.2014.302151. Epub 2014 Oct 16.
PMID: 25322305

5.- Association between higher plasma lutein, zeaxanthin, and vitamin C concentrations and longer telomere length: results of the Austrian Stroke Prevention Study.
Sen A, Marsche G, Freudenberger P, Schallert M, Toeglhofer AM, Nagl C, Schmidt R, Launer LJ, Schmidt H.
J Am Geriatr Soc. 2014 Feb;62(2):222-9. doi: 10.1111/jgs.12644. Epub 2014 Jan 15.
PMID: 24428184

EJERCICIO

1.- Movement-Based Behaviors and Leukocyte Telomere Length among US Adults.
Loprinzi PD, Loenneke JP, Blackburn EH.
Med Sci Sports Exerc. 2015 Nov;47(11):2347-52. doi: 10.1249/MSS.0000000000000695.
PMID: 25970659

 

2.- The power of exercise: buffering the effect of chronic stress on telomere length.
Puterman E, Lin J, Blackburn E, O’Donovan A, Adler N, Epel E.
PLoS One. 2010 May 26;5(5):e10837. doi: 10.1371/journal.pone.0010837.
PMID: 20520771

 

3.- Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors.
Denham J, Nelson CP, O’Brien BJ, Nankervis SA, Denniff M, Harvey JT, Marques FZ, Codd V, Zukowska-Szczechowska E, Samani NJ, Tomaszewski M, Charchar FJ.
PLoS One. 2013 Jul 31;8(7):e69377. doi: 10.1371/journal.pone.0069377. Print 2013.
PMID: 23936000

 

4.- Telomeres and lifestyle factors: roles in cellular aging.
Lin J, Epel E, Blackburn E.
Mutat Res. 2012 Feb 1;730(1-2):85-9. doi: 10.1016/j.mrfmmm.2011.08.003. Epub 2011 Aug 22.
PMID: 21878343

5.- Telomere length and long-term endurance exercise: does exercise training affect biological age? A pilot study.
Østhus IB, Sgura A, Berardinelli F, Alsnes IV, Brønstad E, Rehn T, Støbakk PK, Hatle H, Wisløff U, Nauman J.
PLoS One. 2012;7(12):e52769. doi: 10.1371/journal.pone.0052769. Epub 2012 Dec 26.
PMID: 23300766

FERTILIDAD

1.- Cell-free DNA and telomere length among women undergoing in vitro fertilization treatment.
Czamanski-Cohen J, Sarid O, Cwikel J, Douvdevani A, Levitas E, Lunenfeld E, Har-Vardi I.
J Assist Reprod Genet. 2015 Nov;32(11):1697-703. doi: 10.1007/s10815-015-0581-4. Epub 2015 Oct 5.
PMID: 26438644

 

2.- In young men sperm telomere length is related to sperm number and parental age.
Ferlin A, Rampazzo E, Rocca MS, Keppel S, Frigo AC, De Rossi A, Foresta C.
Hum Reprod. 2013 Dec;28(12):3370-6. doi: 10.1093/humrep/det392. Epub 2013 Oct 27.
PMID: 24166593

 

3.- Analysis of sperm telomere length in men with idiopathic infertility.
Thilagavathi J, Kumar M, Mishra SS, Venkatesh S, Kumar R, Dada R.
Arch Gynecol Obstet. 2013 Apr;287(4):803-7. doi: 10.1007/s00404-012-2632-8. Epub 2012 Nov 20.
PMID: 23179801

 

4.- Telomere length in the newborn.
Okuda K, Bardeguez A, Gardner JP, Rodriguez P, Ganesh V, Kimura M, Skurnick J, Awad G, Aviv A.
Pediatr Res. 2002 Sep;52(3):377-81.
PMID: 12193671

 

5.- Characterization of telomerase activity in the human oocyte and preimplantation embryo.
Wright DL, Jones EL, Mayer JF, Oehninger S, Gibbons WE, Lanzendorf SE.
Mol Hum Reprod. 2001 Oct;7(10):947-55.
PMID: 11574663

 

6.- Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells.
Marion RM, Strati K, Li H, Tejera A, Schoeftner S, Ortega S, Serrano M, Blasco MA.
Cell Stem Cell. 2009 Feb 6;4(2):141-54. doi: 10.1016/j.stem.2008.12.010.
PMID: 19200803

OBESIDAD

1.- Obesity, cigarette smoking, and telomere length in women.
Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, Aviv A, Spector TD.
Lancet. 2005 Aug 20-26;366(9486):662-4.
PMID: 16112303

 

2.- Childhood obesity is associated with shorter leukocyte telomere length.
Buxton JL, Walters RG, Visvikis-Siest S, Meyre D, Froguel P, Blakemore AI.
J Clin Endocrinol Metab. 2011 May;96(5):1500-5. doi: 10.1210/jc.2010-2924. Epub 2011 Feb 24.
PMID: 21349907

ESTRÉS Y DEPRESIÓN

1.- Telomere length is associated with oppositional defiant behavior and maternal clinical depression in Latino preschool children.
Wojcicki JM, Heyman MB, Elwan D, Shiboski S, Lin J, Blackburn E, Epel E.
Transl Psychiatry. 2015 Jun 16;5:e581. doi: 10.1038/tp.2015.71.
PMID: 26080316

 

2.- Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder.
Henje Blom E, Han LK, Connolly CG, Ho TC, Lin J, LeWinn KZ, Simmons AN, Sacchet MD, Mobayed N, Luna ME, Paulus M, Epel ES, Blackburn EH, Wolkowitz OM, Yang TT.
Transl Psychiatry. 2015 Nov 10;5:e676. doi: 10.1038/tp.2015.172.
PMID: 26556285

 

3.- Molecular signatures of major depression.
Cai N, Chang S, Li Y, Li Q, Hu J, Liang J, Song L, Kretzschmar W, Gan X, Nicod J, Rivera M, Deng H, Du B, Li K, Sang W, Gao J, Gao S, Ha B, Ho HY, Hu C, Hu J, Hu Z, Huang G, Jiang G, Jiang T, Jin W, Li G, Li K, Li Y, Li Y, Li Y, Lin YT, Liu L, Liu T, Liu Y, Liu Y, Lu Y, Lv L, Meng H, Qian P, Sang H, Shen J, Shi J, Sun J, Tao M, Wang G, Wang G, Wang J, Wang L, Wang X, Wang X, Yang H, Yang L, Yin Y, Zhang J, Zhang K, Sun N, Zhang W, Zhang X, Zhang Z, Zhong H, Breen G, Wang J, Marchini J, Chen Y, Xu Q, Xu X, Mott R, Huang GJ, Kendler K, Flint J.
Curr Biol. 2015 May 4;25(9):1146-56. doi: 10.1016/j.cub.2015.03.008. Epub 2015 Apr 23.
PMID: 25913401

 

4.- Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.
Lindqvist D, Epel ES, Mellon SH, Penninx BW, Révész D, Verhoeven JE, Reus VI, Lin J, Mahan L, Hough CM, Rosser R, Bersani FS, Blackburn EH, Wolkowitz OM.
Neurosci Biobehav Rev. 2015 Aug;55:333-64. doi: 10.1016/j.neubiorev.2015.05.007. Epub 2015 May 18. Review.
PMID: 25999120

 

5.- Depression and telomere length: A meta-analysis.
Ridout KK, Ridout SJ, Price LH, Sen S, Tyrka AR.
J Affect Disord. 2016 Feb;191:237-47. doi: 10.1016/j.jad.2015.11.052. Epub 2015 Dec 2.
PMID: 26688493

FUMAR

1.- TEffects of cigarette smoking and nicotine metabolite ratio on leukocyte telomere length.
Verde Z, Reinoso-Barbero L, Chicharro L, Garatachea N, Resano P, Sánchez-Hernández I, Rodríguez González-Moro JM, Bandrés F, Santiago C, Gómez-Gallego F.
Environ Res. 2015 Jul;140:488-94. doi: 10.1016/j.envres.2015.05.008. Epub 2015 May 18.
PMID: 25996625

 

2.- Aging-related systemic manifestations in COPD patients and cigarette smokers.
Boyer L, Chouaïd C, Bastuji-Garin S, Marcos E, Margarit L, Le Corvoisier P, Vervoitte L, Hamidou L, Frih L, Audureau E, Covali-Noroc A, Andujar P, Saakashvili Z, Lino A, Ghaleh B, Hue S, Derumeaux G, Housset B, Dubois-Randé JL, Boczkowski J, Maitre B, Adnot S.
PLoS One. 2015 Mar 18;10(3):e0121539. doi: 10.1371/journal.pone.0121539. eCollection 2015.
PMID: 25785739

 

3.- Impact of intrauterine tobacco exposure on fetal telomere length.
Salihu HM, Pradhan A, King L, Paothong A, Nwoga C, Marty PJ, Whiteman V.
Am J Obstet Gynecol. 2015 Feb;212(2):205.e1-8. doi: 10.1016/j.ajog.2014.08.026. Epub 2014 Aug 27.
PMID: 25173189

HISTORIA DE LOS TELÓMEROS

1.- Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.
McEachern MJ, Blackburn EH.
Genes Dev. 1996 Jul 15;10(14):1822-34.
PMID: 8698241

 

2.- Telomeres shorten during ageing of human fibroblasts.
Harley CB, Futcher AB, Greider CW.
Nature. 1990 May 31;345(6274):458-60.
PMID: 2342578

 

3.- Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process.
Ducray C, Pommier JP, Martins L, Boussin FD, Sabatier L.
Oncogene. 1999 Jul 22;18(29):4211-23.
PMID: 10435634

INFLAMACIÓN

1.- Dyslipidemia and chronic inflammation markers are correlated with telomere length shortening in Cushing’s syndrome.
Aulinas A, Ramírez MJ, Barahona MJ, Valassi E, Resmini E, Mato E, Santos A, Crespo I, Bell O, Surrallés J, Webb SM.
PLoS One. 2015 Mar 23;10(3):e0120185. doi: 10.1371/journal.pone.0120185. eCollection 2015.
PMID: 25799396

 

2.- Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.
Franceschi C, Campisi J.
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9. doi: 10.1093/gerona/glu057. Review.
PMID: 24833586

ACTIVADORES DE LA TELOMERASA

1.- The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence.
Bernardes de Jesus B, Schneeberger K, Vera E, Tejera A, Harley CB, Blasco MA.
Aging Cell. 2011 Aug;10(4):604-21. doi: 10.1111/j.1474-9726.2011.00700.x. Epub 2011 Apr 14.
PMID: 21426483

TRASTORNOS NUERODEGENERATIVOS

1.- Association of shorter leukocyte telomere repeat length with dementia and mortality.
Honig LS, Kang MS, Schupf N, Lee JH, Mayeux R.
Arch Neurol. 2012 Oct;69(10):1332-9.
PMID: 22825311
2.- Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use.
Jacobs EG, Kroenke C, Lin J, Epel ES, Kenna HA, Blackburn EH, Rasgon NL.
PLoS One. 2013;8(2):e54713. doi: 10.1371/journal.pone.0054713. Epub 2013 Feb 13.
PMID: 23418430

FIBROSIS PULMONAR

1.- Association between telomere length and survival in patients with idiopathic pulmonary fibrosis.
Dai J, Cai H, Li H, Zhuang Y, Min H, Wen Y, Yang J, Gao Q, Shi Y, Yi L.
Respirology. 2015 Aug;20(6):947-52. doi: 10.1111/resp.12566. Epub 2015 Jun 14.
PMID: 26073170

CÉLULAS MADRE

1.- c-Kit identifies a subpopulation of mesenchymal stem cells in adipose tissue with higher telomerase expression and differentiation potential.
Blazquez-Martinez A, Chiesa M, Arnalich F, Fernandez-Delgado J, Nistal M, De Miguel MP.
Differentiation. 2014 Mar-Apr;87(3-4):147-60. doi: 10.1016/j.diff.2014.02.007. Epub 2014 Apr 6.
PMID: 24713343

 

2.- The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation.
Wang L, Xiao H, Zhang X, Wang C, Huang H.
J Hematol Oncol. 2014 Aug 20;7:61. doi: 10.1186/s13045-014-0061-9. Review.
PMID: 25139287

ALCOHOL

1.- Association between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study.
Strandberg TE, Strandberg AY, Saijonmaa O, Tilvis RS, Pitkälä KH, Fyhrquist F.
Eur J Epidemiol. 2012 Oct;27(10):815-22. doi: 10.1007/s10654-012-9728-0. Epub 2012 Aug 9.
PMID: 22875407

 

2.- TShortened telomeres in individuals with abuse in alcohol consumption..
Pavanello S, Hoxha M, Dioni L, Bertazzi PA, Snenghi R, Nalesso A, Ferrara SD, Montisci M, Baccarelli A.
Int J Cancer. 2011 Aug 15;129(4):983-92. doi: 10.1002/ijc.25999. Epub 2011 Apr 25.
PMID: 21351086

ARTERIOESCLEROSIS

1.- Telomere shortening in atherosclerosis.
Samani NJ, Boultby R, Butler R, Thompson JR, Goodall AH.
Lancet. 2001 Aug 11;358(9280):472-3.
PMID: 11513915

 

2.- Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects.
Benetos A, Gardner JP, Zureik M, Labat C, Xiaobin L, Adamopoulos C, Temmar M, Bean KE, Thomas F, Aviv A.
Hypertension. 2004 Feb;43(2):182-5. Epub 2004 Jan 19.
PMID: 14732735
3.- Biological ageing and cardiovascular disease.
Samani NJ, van der Harst P.
Heart. 2008 May;94(5):537-9. doi: 10.1136/hrt.2007.136010. No abstract available.
PMID: 18411343

CITOMEGALOVIRUS

1.- Cytomegalovirus infection reduces telomere length of the circulating T cell pool.
van de Berg PJ, Griffiths SJ, Yong SL, Macaulay R, Bemelman FJ, Jackson S, Henson SM, ten Berge IJ, Akbar AN, van Lier RA.
J Immunol. 2010 Apr 1;184(7):3417-23. doi: 10.4049/jimmunol.0903442. Epub 2010 Feb 22.
PMID: 20176738

CONSUMO DE DROGAS

1.- Drug addiction is associated with leukocyte telomere length.
Yang Z, Ye J, Li C, Zhou D, Shen Q, Wu J, Cao L, Wang T, Cui D, He S, Qi G, He L, Liu Y.
Sci Rep. 2013;3:1542. doi: 10.1038/srep01542.
PMID: 23528991

HEPATITIS

1.- Telomere reduction in human liver tissues with age and chronic inflammation.
Aikata H, Takaishi H, Kawakami Y, Takahashi S, Kitamoto M, Nakanishi T, Nakamura Y, Shimamoto F, Kajiyama G, Ide T.
Exp Cell Res. 2000 May 1;256(2):578-82.
PMID: 10772830

 

2.- Telomere length in Hepatitis C.
Kitay-Cohen Y, Goldberg-Bittman L, Hadary R, Fejgin MD, Amiel A.
Cancer Genet Cytogenet. 2008 Nov;187(1):34-8. doi: 10.1016/j.cancergencyto.2008.08.006.
PMID: 18992639

HIPERTENSIÓN

1.- Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study.
Vasan RS, Demissie S, Kimura M, Cupples LA, Rifai N, White C, Wang TJ, Gardner JP, Cao X, Benjamin EJ, Levy D, Aviv A.
Circulation. 2008 Mar 4;117(9):1138-44. doi: 10.1161/CIRCULATIONAHA.107.731794. Epub 2008 Feb 11.
PMID: 18268147

 

2.- Leukocyte telomere length, hypertension, and atherosclerosis: are there potential mechanistic explanations?
Aviv A.
Hypertension. 2009 Apr;53(4):590-1. doi: 10.1161/HYPERTENSIONAHA.109.128926. Epub 2009 Mar 2. No abstract available.
PMID: 19255359

 

3.- Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study.
Brouilette SW, Moore JS, McMahon AD, Thompson JR, Ford I, Shepherd J, Packard CJ, Samani NJ; West of Scotland Coronary Prevention Study Group.
Lancet. 2007 Jan 13;369(9556):107-14.
PMID: 17223473

INSOMNIO

1.- Associations between rotating night shifts, sleep duration, and telomere length in women.
Liang G, Schernhammer E, Qi L, Gao X, De Vivo I, Han J.
PLoS One. 2011;6(8):e23462. doi: 10.1371/journal.pone.0023462. Epub 2011 Aug 10.
PMID: 21853136

 

2.- Short sleep duration is associated with shorter telomere length in healthy men: findings from the Whitehall II cohort study.
Jackowska M, Hamer M, Carvalho LA, Erusalimsky JD, Butcher L, Steptoe A.
PLoS One. 2012;7(10):e47292. doi: 10.1371/journal.pone.0047292. Epub 2012 Oct 29.
PMID: 23144701

LUPUS ERITEMATOSO

1.- Shortened telomere length in patients with systemic lupus erythematosus.
Shortened telomere length in patients with systemic lupus erythematosus.

OSTEOPOROSIS

1.- Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis.
Valdes AM, Richards JB, Gardner JP, Swaminathan R, Kimura M, Xiaobin L, Aviv A, Spector TD.
Osteoporos Int. 2007 Sep;18(9):1203-10. Epub 2007 Mar 9.
PMID: 17347788
2.- The effect of telomere length, a marker of biological aging, on bone mineral density in elderly population.
Tang NL, Woo J, Suen EW, Liao CD, Leung JC, Leung PC.
Osteoporos Int. 2010 Jan;21(1):89-97. doi: 10.1007/s00198-009-0948-4. Epub 2009 May 13.
PMID: 19436937

ARTRITIS REUMATOIDE

1.- Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages.
Schönland SO, Lopez C, Widmann T, Zimmer J, Bryl E, Goronzy JJ, Weyand CM.
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13471-6. Epub 2003 Oct 24.
PMID: 14578453

 

2.- Reduced telomere length in rheumatoid arthritis is independent of disease activity and duration.
Steer SE, Williams FM, Kato B, Gardner JP, Norman PJ, Hall MA, Kimura M, Vaughan R, Aviv A, Spector TD.
Ann Rheum Dis. 2007 Apr;66(4):476-80. Epub 2006 Nov 17.
PMID: 17114192

 

3.- Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis.
Colmegna I, Diaz-Borjon A, Fujii H, Schaefer L, Goronzy JJ, Weyand CM.
Arthritis Rheum. 2008 Apr;58(4):990-1000. doi: 10.1002/art.23287.
PMID: 18383391

ESQUIZOFRENIA

1.- Rapid telomere erosion in schizophrenia.
Kao HT, Cawthon RM, Delisi LE, Bertisch HC, Ji F, Gordon D, Li P, Benedict MM, Greenberg WM, Porton B.
Mol Psychiatry. 2008 Feb;13(2):118-9. doi: 10.1038/sj.mp.4002105. No abstract available.
PMID: 18202693

VITAMINAS Y ANTIOXIDANTES

1.- Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women.
Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A.
Am J Clin Nutr. 2007 Nov;86(5):1420-5.
PMID: 17991655
2.- Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease.
Farzaneh-Far R, Lin J, Epel ES, Harris WS, Blackburn EH, Whooley MA.
JAMA. 2010 Jan 20;303(3):250-7. doi: 10.1001/jama.2009.2008.
PMID: 20085953