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Cell Therapy & Gene Therapy2022-08-18T12:05:29+02:00

Cell Therapy
& Gene Therapy

Cell and Gene Therapy

The development of any cell and gene therapy must overcome multiple challenges to avoid failed treatments.

There is a lack of clinically validated tools available to researchers to aid in the monitoring cellular status in a reliable way, and hence contributing to the decision-making process during therapy development.

Cell characterization, vector monitoring and quality assurance through a comprehensive panel of multiple biomarkers can help you address these problems while saving time and money.

Cell Therapies

Cell monitoring and characterization:

  • Cells with short telomeres are closer to senescence. Ensure an optimal telomere length to improve in vivo survival.
  • Verify telomeres are long enough in order to protect plasticity in stem cell-like cells.
  • Stain and measure specific cells types. Ideal for xenografts, focus on different cell populations, origins, etc.

Determine cell infiltration and specific cell-type markers (mTOR, PD1-PDL1, ILs…)

  • Donor/ sample selection: Ensure that you start your cell expansions/processing with the best samples.
  • Biosafety: Hyperactivated telomerase activity is a hallmark of cancer. Monitor telomerase activity to discard potential tumorigenicity after cellular expansions or modifications.

Gene therapies

  • Cells are widely used in gene therapy for multiple purposes. Evaluate cellular status after introducing modifications through telomere length and other important markers.
  • Monitor everything around the expression of your gene therapy.
    • Confirm and quantify the expression of the gene editing system on your target population.
    • Compare and select the vector with the most optimal response.
    • Asses viral tropism and the successful delivery of the desired gene.
    • Distinguish transgene from vector genome ensuring the transfer of the desired gene.

APPLIED EXAMPLES

Select the best donor

Cells with longer telomeres will take more time to achieve senescence.

Monitor your expansion and how far are cells from senescence.

Measure telomere length thorough the whole expansion.

Telomerase activity monitoring.

Quality control. Elevated telomerase levels are associated with tumorigenesis.

Telomere length measurement

Guarantee in vivo survival.

Xenografts

Murine cells (green) and human cancer cells (pink).

CAR-T

Detect CAR-T cells in tumor.

Frequently asked questions

What type of samples can we test?2022-06-08T12:26:16+02:00

We can process any type of cell or tissue: MSCs, iPSCs, T cells, NK cells, xenografts, biopsies, blood, etc. We can also measure specific cell types and targets within the same sample, e.g.: CD3+, PDL1 /PD1, differentiate mouse and human cells, etc.

How is the Logistics process?2022-06-08T12:24:46+02:00

We receive samples from all over the world, every day. It is a very easy process and we will happily guide you through it.

How robust are the measurements?2022-06-08T12:23:36+02:00

We follow very strict quality controls. As an example, for our proprietary TAT technology:

  • Clinically validated.
  • Measurements performed in quintuplicates.
  • Seven control cell lines.
  • Intra-assay coefficient < 5%.
  • More than 10.000 individual telomeres measured.
What type of assays can we perform?2022-06-08T12:20:27+02:00

Despite being experts on telomere biology, we routinely perform measurements of hundreds of other biomarkers. Additionally, we can develop protocols for markers that are currently not on our portfolio. Let us know of your needs.

Which information do we need from your samples?2022-07-05T14:03:07+02:00

We understand that our clients want to protect their intellectual property. We do not require any confidential information from your side and we will assign specific codes for identifying your samples in the lab to guarantee their blinding.

Would you like more information?

For more information or inquiries please contact contractresearch@lifelength.com or fill your information in this form.

OUR CERTIFICATIONS AND LICENSES

We are the most highly accredited clinical laboratory in Spain and the only U.S. Federal laboratory in our country.

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