Cell therapies and stem cells

Telomere Biology and cell therapies

There is a strong relation between the success of cell therapies and telomere biology. First of all cell therapies are a tool of regenerative medicine that aim to treat those illnesses that are a consequence of aging, which is triggered by telomere attrition. Moreover, telomere length is an underlying key factor behind the success of these therapies.

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This extensive replication results in telomere shortening exhausting cells’ replicative potential2.

Clinical implications of the use of stem cells with short telomeres

Loss of:

  • homing capacity3
  • plasticity potential4,5
  • expression of trophic factors 6

As a consecuence:

  • Transplantation does not produce the desired effects or it could be harmful 5,7,8

Life Length can help you optimize cell conditions to minimize telomere attritiongrafica-celulas-1
telomere-shortening
Life Length for transplant quality control in stem cell population

Telomere length and telomerase activity measurements to select ALOGENIC and AUTOLOGOUS cell donor’s

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See how telomere length and telomerase measurements can be applied to cell therapies and stem cells

1. Miura Y. Human bone marrow mesenchymal stromal/stem cells: current clinical applications and potential for hematology. Int J Hematol. 2016, 122–128. 2. Campisi J. et al. Cellular senescence, cancer and aging: the telomere connection. Exper Geron. 2011, 1619–1637. 3. Rombouts WJ. et al. Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture. Leukemia. 2003, 160-170. 4. Bruder SP. et al. Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. JCellBiochem. 1997, 64(2):278-94. 5. Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy. 6. Brohlin M. et al. Aging effect on neurotrophic activity of human mesenchymal stem cells. PLoS. 2012, 7(9):e45052. 7. Stenderup K. et al. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone. 2003, 33(6):919-26. 8. Takalov SV. A number of bone marrow mesenchymal stem cells but neither phenotype nor differentiation capacities changes with age of rats. MolCells. 2007, 31;24(2):255-60. 9. Wang L. et al. The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation. J Hemat Oncol. 2014, 10.1186/s13045-014-0061-9.